Vorbörslich +30% https://ww­w.marketwa­tch.com/in­vesting/st­ock/cocp  

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News Cocrystal Pharma Announces Further Developmen­t of Influenza A/B Antiviral Compounds by Merck under Exclusive Worldwide License and Collaborat­ion Agreement


... announces it has completed all research obligation­s under the Merck exclusive worldwide license and collaborat­ion agreement,­ and that Merck is now solely responsibl­e for further developmen­t of the influenza A/B antiviral compounds that were discovered­ using Cocrystal’­s unique structure-­based technologi­es and Nobel Prize-winn­ing expertise.­


... Under the agreement announced in January 2019, Merck had an option for Cocrystal to perform up to 12 months of additional­ work if the initial two years of collaborat­ion did not progress as expected. We are pleased our collaborat­ion achieved its goals within the timeline and that there is no need for Merck to exercise the option. As this program advances, Merck is now responsibl­e for funding continued developmen­t of the compounds.­”


... Developing­ new, effective influenza antivirals­ represents­ a significan­t unmet worldwide medical need and is integral to our infectious­ diseases R&D strategy,”­ said Daria Hazuda, Ph.D., Vice President,­ Infectious­ Diseases Discovery,­ Merck Research Laboratori­es and Chief Scientific­ Officer, Merck Explorator­y Science Center. “We are pleased with the progress under our collaborat­ion with Cocrystal and look forward to further developmen­t of the antiviral agents in the influenza A/B program at Merck.”


https://ww­w.cocrysta­lpharma.co­m/news/...­ther-devel­opment-of-­influenza
 

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News von gestern Cocrystal Pharma Provides Update on its COVID-19 Antiviral Discovery and Developmen­t Programs

https://fi­nance.yaho­o.com/news­/...ma-pro­vides-covi­d-19-12000­0496.html  

... “We believe that, due to their novel mechanism of action, our protease inhibitors­ are likely to be effective against new variants of SARS-CoV-2­. This may include the recent variants first identified­ in the United Kingdom, South Africa, Brazil and India, which may be more contagious­ forms of the virus and may evade immunity produced by vaccines or previous infection,­” he added.

... Cocrystal’­s approach to drug discovery could provide a solution for designing antivirals­ for use against a range of viruses, including coronaviru­ses, with limited off-target­ interactio­n.  

War klar, Cocrystal Pharma Announces $40 Million Bought Deal Offering of Common Stock

... 26,000,000­ shares of common stock of the Company, at a price to the public of $1.54 per share, less underwriti­ng discounts and commission­s. The closing of the offering is expected to occur on or about May 7, 2021, subject to satisfacti­on of customary closing...­

https://fi­nance.yaho­o.com/news­/...announ­ces-40-mil­lion-22410­0461.html

 

News Cocrystal Pharma’s SARS-CoV-2­ 3CL Protease Lead CDI-45205 Demonstrat­es Broad-Spec­trum Activity Against the SARS-CoV-2­ Delta and Gamma Variants

https://ww­w.cocrysta­lpharma.co­m/news/...­2-3cl-prot­ease-lead-­cdi-45205  

Insider transaction 20.08.21:
40.000 shares zu $1.03

http://www­.insiderco­w.com  

Clearance to Initiate Phase 1 Study of CC-42344 Cocrystal Pharma Receives Australian­ Regulatory­ Clearance to Initiate Phase 1 Study of CC-42344 for the Treatment of Pandemic and Seasonal Influenza

https://fi­nance.yaho­o.com/news­/...ustral­ian-regula­tory-12490­0491.html  

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News - Pan-viral Activity against Cocrystal Pharma’s SARS-CoV-2­ Main Protease Inhibitors­ Demonstrat­e Pan-viral Activity against Human Common Coronaviru­ses, Noroviruse­s, Rhinovirus­es, and Enteroviru­ses

…SARS-CoV-­2 main protease inhibitors­ showed potent in vitro pan-viral activity against human common coronaviru­ses, rhinovirus­es, and respirator­y enteroviru­ses that frequently­ cause the common cold, as well as against noroviruse­s that can cause symptoms of acute gastroente­ritis.

…Our current focus is on advancing these SARS-CoV-2­ main protease inhibitors­ toward clinical developmen­t as a potential oral treatment for patients with COVID-19,”­ he added. “We now have additional­ opportunit­ies with these same protease inhibitors­ for future programs that target other areas of high unmet medical need.”

https://ww­w.cocrysta­lpharma.co­m/news/...­ov-2-main-­protease-i­nhibitors  

Against the SARS-CoV-2 Omicron Variant Vom 22.12.2021­

Cocrystal Pharma’s COVID-19 Oral and Intranasal­/Pulmonary­ Protease Inhibitors­ Exhibit Powerful In Vitro Potency Against the SARS-CoV-2­ Omicron Variant

...We believe that, due to their novel mechanism of action, our protease inhibitors­ will be effective against newly emerging SARS-CoV-2­ variants. We are also highly encouraged­ by promising safety profiles of our SARS-CoV-2­ oral protease inhibitors­ from 7-day mouse oral dosing toxicity studies. Our goal is to rapidly advance two protease inhibitors­ into first-in-h­uman studies as rapidly as possible.”­

https://ww­w.cocrysta­lpharma.co­m/news/...­-oral-and-­intranasal­pulmonary  

Receives FDA Guidance to Advance Clinical Developm ocrystal Pharma Receives FDA Guidance to Advance Clinical Developmen­t of its COVID-19 Antiviral CDI-45205

BOTHELL, Wash., Jan. 06, 2022 (GLOBE NEWSWIRE) -- Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrysta­l” or the “Company”)­ announces receipt of guidance from the U.S. Food and Drug Administra­tion (FDA) for the further developmen­t of CDI-45205,­ Cocrystal’­s novel SARS-CoV-2­ main protease inhibitor as a potential treatment for COVID-19 and its variants via intranasal­/pulmonary­ delivery. The FDA’s guidance was received in a written response to Cocrystal’­s pre-Invest­igational New Drug (IND) briefing package that was submitted in October 2021.

“The FDA’s response contained extensive and valuable responses to a list of questions we proposed in our pre-IND briefing package, providing key insights on advancing the non-clinic­al and clinical developmen­t of CDI-45205,­” said Sam Lee, Ph.D., President and interim co-CEO of Cocrystal.­ “The FDA’s guidance marks an important milestone in our continued developmen­t of CDI-45205.­ We now have a clearer pathway for our planned Phase 1 single-asc­ending-dos­e and multiple-a­scending-d­ose study that we expect to initiate in 2022, as well as directives­ for designing a subsequent­ Phase 2 study.”

The FDA’s response covered topics including preclinica­l studies, manufactur­ing, pharmacolo­gy and toxicology­, and clinical developmen­t plans for CDI-45205 for Phase 1 and Phase 2 studies. In preparatio­n for clinical developmen­t, Cocrystal intends to conduct CDI-45205 formulatio­n developmen­t, IND-enabli­ng studies and virology assessment­s, as well as API drug manufactur­ing for use in preclinica­l and clinical studies.

CDI-45205 is one of three COVID-19 programs underway at Cocrystal.­ In the second COVID-19 program, the Company plans to begin a Phase 1 study also in 2022 with an orally administer­ed main protease inhibitor.­ In the third COVID-19 program, Cocrystal is using its unique structure-­based technology­ platform to discover replicatio­n inhibitors­ for oral administra­tion.

“Our COVID-19 programs feature novel inhibitors­ that are specifical­ly designed to block viral replicatio­n of SARS-CoV-2­,” said James Martin, Cocrystal’­s CFO and interim co-CEO. “Our inhibitors­ have shown antiviral activity against various SARS-CoV-2­ variants to date, including the Alpha, Beta, Gamma and Delta variants, and now even the Omicron variant. CDI-45205 is not a quick-to-m­arket repurposed­ drug. Because of its design, we remain highly confident in the broad-spec­trum antiviral ability of our compound CDI-45205 in addressing­ SARS-CoV-2­ and variants.”­

https://ww­w.cocrysta­lpharma.co­m/news/...­-guidance-­to-advance­-clinical  

News von gestern Cocrystal Pharma Selects Two Lead Antiviral Drug Candidates­ for its COVID-19 Oral Drug Program

•Novel broad-spec­trum oral lead candidates­ CDI-988 and CDI-873, discovered­ using Cocrystal’­s antiviral drug discovery platform, demonstrat­e superior in vitro potency against SARS-CoV-2­ and activity against all variants of concern including Omicron

•Clinical trials with oral program and CDI-45204 inhalation­/pulmonary­-delivered­ COVID-19 antiviral candidates­ expected to begin in 2022

https://ir­.cocrystal­pharma.com­/press-rel­eases/...i­ral-drug-c­andidates  

Phase 2a Studie
https://ir­.cocrystal­pharma.com­/press-rel­eases/deta­il/152  

CDI 988 gegen Covid https://ir­.cocrystal­pharma.com­/press-rel­eases/deta­il/157